PubMed Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/18qXwtxF-9k/bibliography/public/
Godfrey WH, Hwang S, Cho K, Shanmukha S, Gharibani P, Abramson E, Kornberg MD. Therapeutic potential of blocking GAPDH nitrosylation with CGP3466b in experimental autoimmune encephalomyelitis. Frontiers in Neurology (2023) 13:979659 doi: 10.3389/fneur.2022.979659 https://www.frontiersin.org/articles/10.3389/fneur.2022.979659/full
Fitzgerald KC, Bhargava P, Smith MD, Vizthum D, Henry-Barron B, Kornberg MD, Cassard SD, Kapogiannis D, Sullivan P, Baer DJ, Calabresi PA, Mowry EM. Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis. eBioMedicine (2022) 82:104124. PubMed PMID: 35816900. https://www.sciencedirect.com/science/article/pii/S235239642200305X?via%3Dihub
Vasavda C, Semenza ER, Liew J, Kothari R, Dhindsa RS, Shanmukha S, Lin A, Tokhunts R, Ricco C, Snowman AM, Albacarys L, Pastore F, Ripoli C, Grassi C, Barone E, Kornberg MD, Dong X, Paul BD, Snyder SH. Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. Science Signaling (2022) 15:3066
Nagpal L, Kornberg MD, Snyder SH. Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling. Proc Natl Acad Sci U.S.A. (2022) 119: e2121946119
Gadani SP, Kornberg MD. DICAM, a molecular passport for TH17 cell entry into the brain. Science Translational Medicine. (2022) Jan 5;14(626):eabm7204. doi: 10.1126/scitranslmed.abm7204. Epub 2022 Jan 5. PubMed PMID: 34985968. Free link: https://www.science.org/stoken/author-tokens/ST-250/full
Kim PM, Kornberg MD. Targeting PKC in microglia to promote remyelination and repair in the CNS. Curr Opin Pharmacol. (2021) Dec 26;62:103-108. doi: 10.1016/j.coph.2021.11.008. [Epub ahead of print] Review. PubMed PMID: 34965482 https://www.sciencedirect.com/science/article/pii/S1471489221001739?via%3Dihub
Fitzgerald KC, Smith MD, Kim S, Sotirchos ES, Kornberg MD, Douglas M, Nourbakhsh B, Graves J, Rattan R, Poisson L, Cerghet M, Mowry EM, Waubant E, Giri S, Calabresi PA, Bhargava P. Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism. Cell Reports Med. (2021) 2(10):100424. doi:10.1016/J.XCRM.2021.100424
Semenza ER, Harraz MM, Abramson E, Malla AP, Vasavda C, Gadalla MM, Kornberg MD, Snyder SH, Roychaudhuri R. D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain. Proceedings of the National Academy of Sciences USA. (2021) Sep 28;118(39). doi: 10.1073/pnas.2110610118. PMID: 34556581
Gharagozloo M, Smith MD, Jin J, Garton T, Taylor M, Chao A, Meyers K, Kornberg MD, Zack DJ, Ohayon J, Calabresi BA, Reich DS, Eberhart CG, Pardo CA, Kemper C, Whartenby KA, Calabresi PA. Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation. Acta Neuropathologica (2021) Sep 6;. doi: 10.1007/s00401-021-02366-4. PMID: 34487221
Marsh EB, Kornberg M, Kessler K, Haq I, Patel AD, Nath A, Schierman B, Jones LK, Quality Committee of the American Academy of Neurology. COVID-19 and Vaccination in the Setting of Neurologic Disease: An Emerging Issue in Neurology. Neurology. (2021) Jul 29: 10.1212/WNL.0000000000012578. doi:10.1212/WNL.0000000000012578. PMID: 34326180 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575134/
Nagpal L, Kornberg MD, Albacarys LK, Snyder SH. Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B. Proceedings of the National Academy of Sciences USA. (2021) 118: e2020695118. PMID: 33547244
Abramson E, Hardman T, Shimizu A, Hwang S, Hester LD, Snyder SH, Wender PA, Kim PM, Kornberg MD. Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation. Cell Chemical Biology (2021) 28, 1-9. doi: https://doi.org/10.1016/j.chembiol.2020.12.015 https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30524-9#articleInformation (free link: https://authors.elsevier.com/a/1cRTb8jWWJjFLX)
Godfrey WH and Kornberg MD. The Role of Metabolic Enzymes in the Regulation of Inflammation. Metabolites (2020) 10, 426 https://www.mdpi.com/2218-1989/10/11/426#cite
Kornberg MD. The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity. WIREs Syst Biol Med. (2020), e1486. https://doi.org/10.1002/wsbm.1486 https://onlinelibrary.wiley.com/doi/full/10.1002/wsbm.1486
Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, and Putluri N. DNA methylation patterns in bladder tumors of African-American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis (2019) gz128, doi.org/10.1093/carcin/bgz128. PMID: 31284295 https://academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgz128/5529845
Bhargava P, Fitzgerald KC, Venkata SLV, Smith MD, Kornberg MD, Mowry EM, Haughey NJ, and Calabresi PA. Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes. Annals of Clinical and Translational Neurology (2018) 6(1): 33-45. doi: 10.1002/acn3.676 https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.676
Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, and Snyder SH. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science (2018) 360(6387): 449-453. doi: 10.1126/science.aan4665. Epub 2018 Mar 29.
https://science.sciencemag.org/content/360/6387/449.long
Kornberg MD, Smith MD, Shirazi HA, Calabresi PA, Snyder SH, and Kim PM. Bryostatin-1 alleviates experimental multiple sclerosis. Proceedings of the National Academy of Sciences USA (2018) 115(9): 2186-2191. doi: 10.1073/pnas.1719902115. https://www.pnas.org/content/115/9/2186.long
Yeshokumar AK, Saylor D, Kornberg MD, and Mowry EM. Evidence for the importance of vitamin D status in neurologic conditions. Curr Treat Options Neurol (2015) 17:51. PMID: 26538263 https://link.springer.com/article/10.1007%2Fs11940-015-0380-3
Kornberg MD, Ratchford JN, Subramaniam RM, and Probasco JC. Giant cell arteritis mimicking infiltrative leptomeningeal disease of the optic nerves. BMJ Case Rep (2015) Apr 9. PMID: 25858943 https://casereports.bmj.com/content/2015/bcr-2014-209160.long
Kornberg MD and Newsome SD. Unmasking and provoking severe disease activity in a patient with NMO spectrum disorder. Neurol Neuroimmunol Neuroinflamm (2015) 2: e66. PMID: 25738165 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335815/
Kornberg MD, Sen N, Hara MR, Juluri KR, Nguyen JVK, Snowman AM, Law L, Hester LD, and Snyder SH. GAPDH mediates nitrosylation of nuclear proteins. Nature Cell Biology (2010) 12(11): 1094-100. doi: 10.1038/ncb2114. https://www.nature.com/articles/ncb2114
Sen N, Hara MR, Kornberg MD, Cascio MD, Bae BI, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, and Sawa A. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature Cell Biology (2008) 10(7): 866-73. doi: 10.1038/ncb1747. https://www.nature.com/articles/ncb1747
Van Rossum DB, Patterson RL, Sharma S, Barrow RK, Kornberg M, Gill DL, and Snyder SH. Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 434(7029): 99-104. doi: 10.1038/nature03340 https://www.nature.com/articles/nature03340
Kornberg Lab 